American Journal of Chinese Medicine, Vol.XXIII, Nos.3-4, pp. 289-298
？ 1995 Institute for Advanced Research in Asian Science and Medicine

12. Effects of Ganoderma Lucidum and Krestin on Subset T-cell in Spleen of γ-irradiated Mice

作者Wang-Chi Chen, Dou-Mong Hau, Chin-Chun Wang, I-Hsin Lin, and Shiuh-Sheng Lee
Insitute of Radiation Biology, National Tsing Hau University, 101. Section 2. Kuang Fu Road, Hsinchu, Taiwan
Department of Common Subject, Chung San Medical and Dental College, Taichung
Department of Chinese Medicine and Hospital, China Medical College, Taichung
Department of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan
To whom correspondence should be addressed
（Accepted for publication May 5, 1995）

Abstract: Effects of Ganoderma Lucidum(Gl) and Krestin(PSK) extracts on spleen , thymus and splenocytes in γ-irradiated mice were investigated in this study. ICR strain male mice were divided into five groups. Group A is normal control. Group B, the experimental control, was treated with Gl. Group C, the radiation treatment control, was treated with whole body exposure to 4 Gyγ-irradiation (RT). Group D was treated with RT and Gl. Group E was treated with RT and PSK. The dosage of Gl was 400 mg/day/kg body weight and PSK was 500 mg/day/kg body weight. Our results indicated that the relative thymus weight in Groups D and E were higher than group C on day 28 after γ-irradiation, Group D was the highest in all the experimental groups. CD4 and CD8 splenocytes in group D were higher than group C on days 7 and 28. Gl was better than PSK in repairing the damaged of subset T-cells in the spleen ofγ-irradiated mice.