中華民國癌症醫學會會刊 5(3), 22-28, 1984

IN VIVO ANTITUMOR EFFECT OF CRUDE EXTRACTS FROM THE MYCELIUM OF GANODERMA LUCIDUM

Shiuh-Sheng Lee, Fu-Du Chen, Shenq-Chyi Chang, Yau-Huei Wei, Irene Liu, Chieh-Fu Chen, Ru-Dong Wei, Kuang-Yao Chen and Paul Wei Han

論文摘要Ganoderma lucidum belongs to the basidiomycotina class of fungi. Extracts from the fruiting body of G. lucidum have been proved to be able to inhibit the growth of Sarcoma 180 tumor in ICR mice. However, the mechanism of antitumor activity of G. lucidum remains unclear. Recently, we have been able to culture G. lucidum in our laboratory to keep a constant supply of the material for experiments. Experiments using serial intraperitoneal injections of the mycelium extracts of G. lucidum (GL-P) to male and female C3H mice showed that the effect of inhibiting the fibrosarcoma growth in both male and female C3H mice was significant (p＜0.05). the antittumor effect of GL-P was enhanced when used in combination with bleomycin (p＜0.01). On the other hand, lung colony assay method was used to measure the effect of GL-P on the rate of metastasis and the results were consistent with the fibrosarcoma test.